when they die they are destroyed by in the liver and spleen ?

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https://quizlet.com › 258298175 › chapter-18-cardiovascular-system-blood-flash-cards

https://quizlet.com › 258298175 › chapter-18-cardiovascular-system-blood-flash-cards
Chapter 18 – Cardiovascular System: Blood Flashcards | Quizlet
When they die, they are destroyed by _____ in the liver and spleen. Macrophages This process releases ____________ to be stored in the liver and bile pigments to be excreted.

https://quizlet.com › 233441614 › ch-18-online-homework-flash-cards

https://quizlet.com › 233441614 › ch-18-online-homework-flash-cards
CH. 18 Online homework Flashcards | Quizlet
These cells are produced by the bone marrow and have a lifespan of 3 to 4 ____ When they die, they are destroyed by ____ in the liver and spleen. This process releases ____ to be stored in the liver and bile pigments to be excreted. red million months macrophages iron Sets with similar terms Ch. 6 Cardiovascular System: Blood idebbielee

https://sicklecellanemianews.com › news › dying-red-blood-cells-iron-deconstructed-in-liver-not-spleen-surprise

https://sicklecellanemianews.com › news › dying-red-blood-cells-iron-deconstructed-in-liver-not-spleen-surprise
Dying Red Blood Cells and Their Iron End Up in Liver, not Spleen
They found that as the number of damaged blood cells started rising in the blood, a particular type of immune cells called monocytes jumped into action. Researchers observed monocytes engulfing damaged red blood cells and taking them to both the spleen and the liver. When checking back a couple of hours later, the team was surprised to find nearly all of the damaged cells inside another type of immune cell known to engulf old cells and other cellular debris — macrophages …

https://pubmed.ncbi.nlm.nih.gov › 28535799

https://pubmed.ncbi.nlm.nih.gov › 28535799
The spleen in liver cirrhosis: revisiting an old enemy with novel …
The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight …

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https://www.studystack.com › flashcard-3037090
Free Biology Flashcards about HW/ ch 18 – StudyStack
When they die, they are destroyed by _____ in the liver and spleen. macrophages: This process releases _____ to be stored in the liver and bile pigments to be excreted. iron: Granulocytes: Neutrophil; Basophil; Eosinophil: Agranulocyte: Monocyte; T-lymphocyte; B-lymphocyte; Macrophage; Plasma cell: Albumin: Protein that maintains osmotic pressure: Globulin

https://pubmed.ncbi.nlm.nih.gov › 1202578

https://pubmed.ncbi.nlm.nih.gov › 1202578
Liver, gallbladder, and spleen – PubMed
The size, shape, and contour of the liver, spleen, and gallbladder can be adequately defined. Ultrasound is a major tool in the diagnosis of jaundice for it can differentiate between extrinsic jaundice in patients who may require surgical intervention and intrinsic jaundice in a patient who requires only medical attention.

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humanphysiology.academy › Introduction to PathoPhysiology › Lect 5 › RBCdestruction.html
RBC destruction – humanphysiology.academy
In the spleen, the components of the old destroyed RBC’s are recycled! 2. Fe => Transferrin => Ferritin. In other words, the iron is stored and saved. 3. The globine is converted back into its amino acids which can be used for building other proteins. 4. The heme is processed in a very special manner: 5.

https://quizlet.com › 4220701 › blood-flash-cards

https://quizlet.com › 4220701 › blood-flash-cards
Blood Flashcards | Quizlet
RBC’s are produced by the bone marrow and have a life span of about ________. 3 to 4 months. When RBC’s die they are destroyed by the _______ in the liver & spleen. macrophages. ______ are responsible for the defense system in the body. WBC’s There are apprx ________ white blood cells per microliter of blood. 5 to 10 thousand

https://pubmed.ncbi.nlm.nih.gov › 27417974

https://pubmed.ncbi.nlm.nih.gov › 27417974
The spleen dictates platelet destruction, anti-platelet antibody …
Although splenectomy may raise platelet counts, antibody-coated platelets and cytotoxic T lymphocytes appear to persist or can change over time. To better understand how the spleen may affect anti-platelet immune responses, we used a murine model of ITP demonstrating both antibody-mediated and T lymphocyte-mediated thrombocytopenia. Mice with severe combined immunodeficiency (SCID) were either splenectomized or not and transfused with splenocytes from CD61 (GPIIIa) knockout mice immunized …

https://quizlet.com › 187478347 › chapter-14-anatomy-and-physiology-ii-flash-cards

https://quizlet.com › 187478347 › chapter-14-anatomy-and-physiology-ii-flash-cards
Chapter 14- Anatomy and Physiology II Flashcards | Quizlet
When these cells die. they are destroyed by cells in the liver and spleen called _____. macrophages This process releases ________,which can be stored in the liver and _________, which will be excreted via the intestines.

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Find sources: Splenectomy – news · newspapers · books · scholar · JSTOR (August 2016) (Learn how and when to remove this template message)
Splenectomy
Surgically removed spleen of a child with thalassemia. It is about 15 times larger than normal.
ICD-9-CM 41.43, 41.5
MeSH D013156
OPS-301 code 5-413
[edit on Wikidata]
A splenectomy is the surgical procedure that partially or completely removes the spleen. The spleen is an important organ in regard to immunological function due to its ability to efficiently destroy encapsulated bacteria. Therefore, removal of the spleen runs the risk of overwhelming post-splenectomy infection, a medical emergency and rapidly fatal disease caused by the inability of the body’s immune system to properly fight infection following splenectomy or asplenia.[1]
Common indications for splenectomy include trauma, tumors, splenomegaly or for hematological disease such as sickle cell anemia or thalassemia.[2]
Contents
1 Indications
2 Procedure
3 Side effects
4 Subtotal splenectomy
5 See also
6 References
Indications[edit]
The spleen is an organ located in the abdomen next to the stomach. It is composed of red pulp which filters the blood, removing foreign material, damaged and worn out red blood cells. It also functions as a storage site for iron, red blood cells and platelets. The rest (~25%) of the spleen is known as the white pulp and functions like a large lymph node being the largest secondary lymphoid organ in the body.[3] Apart from regular lymphatic function the white pulp contains splenic macrophages which are particularly good at destroying (phagocytosis) encapsulated bacteria such as Streptococcus pneumoniae.[4] The spleen is also known to function as a site for the development of new red blood cells from their hematopoietic stem cell precursors, and particularly in situations in which the bone marrow, the normal site for this process, has been compromised by a disorder such as leukemia. The spleen is enlarged in a variety of conditions such as malaria, mononucleosis and most commonly in cancers of the lymphatics, such as lymphomas or leukemia.
It is removed under the following circumstances:
When it becomes very large such that it becomes destructive to platelets/red blood cells or rupture is imminent
For diagnosing certain lymphomas
Certain cases of splenic abscess
Certain cases of wandering spleen
Splenic vein thrombosis with bleeding Gastric varices
When platelets are destroyed in the spleen as a result of an auto-immune condition, such as idiopathic thrombocytopenic purpura.
When the spleen bleeds following physical trauma
Following spontaneous rupture
For long-term treatment of congenital erythropoietic porphyria (CEP) if severe hemolytic anemia develops[5]
The spread of gastric cancer to splenic tissue
When using the splenic artery for kidney revascularisation in renovascular hypertension.
For long-term treatment of congenital pyruvate kinase (PK) deficiency
Those who have a severe version of the hereditary blood disorder Spherocytosis.
During surgical resection of a pancreatic cancer
The classical cause of traumatic damage to the spleen is a blow to the abdomen during a sporting event. In cases where the spleen is enlarged due to illness (mononucleosis), trivial activities, such as leaning over a counter or straining while defecating, can cause a rupture.
Procedure[edit]
Laparoscopy is the preferred procedure in cases where the spleen is not too large and when the procedure is elective. Open surgery is performed in trauma cases or if the spleen is enlarged. Either method is major surgery and is performed under general anesthesia. Vaccination for S. pneumoniae, H. influenza and N. meningitidis should be given pre-operatively if possible to minimize the chance of overwhelming post-splenectomy infection (OPSI), a rapid-developing and highly fatal type of septicaemia. The spleen is located and disconnected from its arteries. The ligaments holding the spleen in place, gastrosplenic ligament, splenorenal ligament and splenocolic ligament, are dissected and the organ is removed. In some cases, one or more accessory spleens are discovered and also removed during surgery. The incisions are closed and when indicated, a drain is left. If necessary, tissue samples are sent to a laboratory for analysis.[citation needed]
Side effects[edit]
Splenectomy causes an increased risk of sepsis, particularly overwhelming post-splenectomy sepsis due to encapsulated organisms such as S. pneumoniae and Haemophilus influenzae which are no longer able to be destroyed.[4] It has been found that the risk of acquiring sepsis is 10 to 20 times higher in a splenectomized patient compared to a non-splenectomized patient, which can result in death, especially in young children.[6] Therefore, patients are administered the pneumococcal conjugate vaccine (Prevnar), Hib vaccine, and the meningococcal vaccine post-operatively (see asplenia). These bacteria often cause a sore throat under normal circumstances but after splenectomy, when infecting bacteria cannot be adequately opsonized, the infection becomes more severe.[citation needed]
Splenectomy also increases the severity of babesiosis, Splenectomized patients are more susceptible to contracting babesiosis and can die within five to eight days of symptom onset.[7] They have severe hemolytic anemia, and occasional hepatomegaly has been documented. Parasitemia levels can reach up to 85% in patients without spleens, compared to 1–10% in individuals with spleens and effective immune systems.[8]
An increase in blood leukocytes can occur following a splenectomy.[9] The post-splenectomy platelet count may rise to abnormally high levels (thrombocytosis), leading to an increased risk of potentially fatal clot formation. Mild thrombocytosis may be observed after a splenectomy due to the lack of sequestering and destruction of platelets that would normally be carried out by the spleen. In addition, the splenectomy may result in a slight increase in the production of platelets within the bone marrow. Normally, erythrocytes are stored and removed from the circulating blood by the spleen, including the removal of damaged erythrocytes. However, after a splenectomy the lack of presence of the spleen means this function cannot be carried out so damaged erythrocytes will continue to circulate in the blood and can release substances into the blood. If these damaged erythrocytes have a procoagulant activity then the substances they release can lead to the development of a procoagulant state and this can cause thromboembolic events e.g. pulmonary embolism, portal vein thrombosis and deep vein thrombosis.[6] There also is some conjecture that post-splenectomy patients may be at elevated risk of subsequently developing diabetes.[10] Splenectomy may also lead to chronic neutrophilia. Splenectomy patients typically have Howell-Jolly bodies[11][12] and less commonly Heinz bodies in their blood smears.[13] Heinz bodies are usually found in cases of G6PD (Glucose-6-Phosphate Dehydrogenase) and chronic liver disease.[14]
A splenectomy also results in a greatly diminished frequency of memory B cells.[15] A 28-year follow-up of 740 World War II veterans who had their spleens removed on the battlefield showed a significant increase in the usual death from pneumonia (6 deaths rather than the expected 1.74) and an increase in the deaths from ischemic heart disease (41 deaths rather than the expected 30.26) but not from other conditions.[16]
Subtotal splenectomy[edit]
Much of the spleen’s protective roles can be maintained if a small amount of spleen can be left behind.[17] Where clinically appropriate, attempts are now often made to perform either surgical subtotal (partial) splenectomy,[18] or partial splenic embolization.[19] In particular, whilst vaccination and antibiotics provide good protection against the risks of asplenia, this is not always available in poorer countries.[20] However, as it may take some time for the preserved splenic tissue to provide the full protection, it has been advised that preoperative vaccination still be given.[21]
See also[edit]
Asplenia
Autosplenectomy
Overwhelming post-splenectomy infection
Lymphatic system
Infectious mononucleosis
List of surgeries by type
References[edit]
^ Taniguchi, Leandro Utino; Correia, Mário Diego Teles; Zampieri, Fernando Godinho (December 2014). Overwhelming post-splenectomy infection: narrative review of the literature. Surgical Infections. 15 (6): 686–693. doi:10.1089/sur.2013.051. ISSN 1557-8674. PMID 25318011.
^ Weledji, Elroy P. (2014). Benefits and risks of splenectomy. International Journal of Surgery (London, England). 12 (2): 113–119. doi:10.1016/j.ijsu.2013.11.017. ISSN 1743-9159. PMID 24316283.
^ Cesta, Mark F. (2006). Normal structure, function, and histology of the spleen. Toxicologic Pathology. 34 (5): 455–465. doi:10.1080/01926230600867743. ISSN 0192-6233. PMID 17067939. S2CID 39791978.
^
a b Di Sabatino, Antonio; Carsetti, Rita; Corazza, Gino Roberto (2011-07-02). Post-splenectomy and hyposplenic states. Lancet. 378 (9785): 86–97. doi:10.1016/S0140-6736(10)61493-6. ISSN 1474-547X. PMID 21474172. S2CID 30554953.
^ Frye R. (2006-03-02). Porphyria, Cutaneous. eMedicine. Retrieved 2006-03-28.
^
a b Tarantino G, Scalera A, Finelli C (June 2013). Liver-spleen axis: intersection between immunity, infections and metabolism. World Journal of Gastroenterology. 19 (23): 3534–42. doi:10.3748/wjg.v19.i23.3534. PMC 3691032. PMID 23801854.
^ Babesiosis. National Institute of Allergy and Infectious Diseases, National Institutes of Health. 2009-02-19. d from the original on 2009-03-05.
^ Gelfand, Jeffrey A.; Vannier, Edouard (6 March 2008). Ch. 204: Babesiosis. Harrison’s Principles of Internal Medicine, 17e. McGraw-Hill’s Access Medicine. ISBN 978-0071466332.
^ Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force (February 1996). Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. BMJ. 312 (7028): 430–4. doi:10.1136/bmj.312.7028.430. PMC 2350106. PMID 8601117.
^ Kolata G (9 November 2004). A Diabetes Researcher Forges Her Own Path to a Cure. The New York Times.
^ synd/1596 at Who Named It?
^ Katcher AL (Mar 1980). Familial asplenia, other malformations, and sudden death. Pediatrics. 65 (3): 633–5. doi:10.1542/peds.65.3.633. PMID 7360556. S2CID 25109676.
^ Rodak B, Fritsma G, Doig K. Hematology: Clinical Principles and Applications.
^ Irwin JJ, Kirchner JT (October 2001). Anemia in children. American Family Physician. 64 (8): 1379–86. PMID 11681780.
^ Kruetzmann S, Rosado MM, Weber H, Germing U, Tournilhac O, Peter HH, Berner R, Peters A, Boehm T, Plebani A, Quinti I, Carsetti R (April 2003). Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. The Journal of Experimental Medicine. 197 (7): 939–45. doi:10.1084/jem.20022020. PMC 2193885. PMID 12682112.
^ Robinette CD, Fraumeni JF (July 1977). Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet. 2 (8029): 127–9. doi:10.1016/S0140-6736(77)90132-5. PMID 69206. S2CID 38605411.
^ Grosfeld JL, Ranochak JE (June 1976). Are hemisplenectomy and/or primary splenic repair feasible?. Journal of Pediatric Surgery. 11 (3): 419–24. doi:10.1016/S0022-3468(76)80198-4. PMID 957066.
^ Bader-Meunier B, Gauthier F, Archambaud F, Cynober T, Miélot F, Dommergues JP, Warszawski J, Mohandas N, Tchernia G (January 2001). Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis. Blood. 97 (2): 399–403. doi:10.1182/blood.V97.2.399. PMID 11154215. S2CID 22741973.
^ Pratl B, Benesch M, Lackner H, Portugaller HR, Pusswald B, Sovinz P, Schwinger W, Moser A, Urban C (January 2008). Partial splenic embolization in children with hereditary spherocytosis. European Journal of Haematology. 80 (1): 76–80. doi:10.1111/j.1600-0609.2007.00979.x. PMID 18028435. S2CID 41343243.
^ Sheikha AK, Salih ZT, Kasnazan KH, Khoshnaw MK, Al-Maliki T, Al-Azraqi TA, Zafer MH (October 2007). Prevention of overwhelming postsplenectomy infection in thalassemia patients by partial rather than total splenectomy. Canadian Journal of Surgery. 50 (5): 382–6. PMC 2386178. PMID 18031639.
^ Kimber C, Spitz L, Drake D, Kiely E, Westaby S, Cozzi F, Pierro A (June 1998). Elective partial splenectomy in childhood. Journal of Pediatric Surgery. 33 (6): 826–9. doi:10.1016/S0022-3468(98)90651-0. PMID 9660206.
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