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**Title: The Truth About Derek Shepherd’s Affairs in Grey’s Anatomy**

**Introduction:**
Grey’s Anatomy, known for its intricate plotlines and character dynamics, often leaves fans questioning the complexities of its relationships. One such question that frequently arises is whether Derek Shepherd cheated on Meredith Grey and, if so, with whom. This blog post aims to clarify the timeline of events and address common misconceptions.

**Addison’s Affair:**
Before the series began, Addison Shepherd cheated on Derek with his best friend, Mark Sloan. This betrayal led her to return to Seattle, seeking reconciliation. However, their marriage faced another significant blow when Derek, in turn, cheated on Addison with Meredith Grey.

**Derek’s Affair with Meredith:**
Derek’s infidelity with Meredith led to the dissolution of his marriage with Addison. This affair was a pivotal moment in the series, setting the stage for Meredith and Derek’s eventual relationship.

**The DC Incident:**
In a later season, Derek was involved with an intern in DC while married to Meredith. This incident, though minor compared to the affair with Addison, further highlighted Derek’s pattern of infidelity.

**Meredith’s Loyalty:**
Contrary to some beliefs, Meredith did not cheat on Derek in Season 11. Her actions were driven by personal struggles, not infidelity.

**Conclusion:**
The key betrayal in Derek’s life was his affair with Meredith, which led to his divorce from Addison. While he had minor dalliances, such as with the DC intern, Meredith herself remained loyal. Understanding this timeline helps fans appreciate the depth and complexity of the characters’ relationships in Grey’s Anatomy.