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what to unlock first isaac ?

### Unveiling the Secrets of Unlocking in The Binding of Isaac: Rebirth

In the depths of The Binding of Isaac: Rebirth, players are often faced with a multitude of choices, each leading to a different path when it comes to unlocking items and characters. Whether you’re a seasoned veteran or a new player curious about where to start, which items are best to unlock first can often feel like a labyrinth of secrets to uncover. Today, we’ll explore some tips and strategies for unlocking the most beneficial items and characters in Isaac, based on community advice and expert opinions.

#### Character Strategy: Who to Focus On?

Most players agree that to navigate the varied challenges of Isaac’s worlds, the first character you might want to unlock is Magdalene. She offers a unique starting scenario with more hearts than others, making her a comforting companion for beginners. After that, unlocking Bethany is essential because she provides one of the game’s most impactful items, the Urn of Souls, upon defeating Satan.

#### Key Items to Unlock

– **Mom’s Knife (Isaac)**: Vital for boosting Isaac’s overall damage output and a must-have for progression.
– **Urn of Souls (Bethany)**: Once Bethany has fulfilled her role, defeating Satan with her rewards an extremely powerful add-on.
– **Maggy’s Faith (Magdalene)**: Unlocking Magdalene leads to the acquisition of Maggy’s Faith, a powerful multiplier and a boss-killer.
– **Judas’s Tongue (Judas)**: Unlocked by defeating Satan as Judas, it’s an item that gains buffs when Judas kills enemies.
– **???’s Soul** (Secret character ???): For the adventurous, unlocking this item by defeating Satan as ??? significantly enhances your item pool with its unique ability to pick up any random item.

#### Unlocking Sequence and Challenges

– **Red Key**: One of the more straightforward items, the Red Key is unlocked by completing five blue doors in a single run and can be a gateway to finding new and sometimes much stronger items.
– **Epic Fetus**: A challenging item to unlock, but very powerful with gameplay-changing effects. Defeating Cain or Satan as Cain can pave the way to make it worth the extra effort.
– **The D6**: An often-requested card that can change the game mechanics dramatically with each face offering unique effects and powers.

#### Tips and Tricks

When unlocking items or characters, it’s important to consider the specific playstyle you prefer. Some items suit a more aggressive approach, while others are better suited for those who like to play strategically, avoiding direct confrontation. The key here is diversity: unlocking a variety can not only enhance your character’s survivability but also opens up a world of different strategies.

#### Conclusion

Unlocking items and characters in The Binding of Isaac: Rebirth can be both a strategic and a reward-driven endeavor. By focusing on unlocking the right combination of powerful characters and items, and honing in on those that complement your game style, you can enhance your experience and overall success in the game. Don’t forget to check out community forums and player guides for additional insights and strategies. Happy exploring, treasure hunters!