where and/or when is telomerase typically expressed ?

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where and/or when is telomerase typically expressed ?

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https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/telomeres-telomerase

https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/telomeres-telomerase
Telomeres and telomerase (article) | Khan Academy
Telomerase is not usually active in most somatic cells (cells of the body), but it’s active in germ cells (the cells that make sperm and eggs) and some adult stem cells. These are cell types that need to undergo many divisions, or, in the case of germ cells, give rise to a new organism with its telomeric clock reset 5 ‍ .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC120798

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC120798
Human Telomerase and Its Regulation – PMC – National Center for …
Importantly, among the core components of human telomerase, only the catalytic component hTERT seems to be the limiting determinant of telomerase activity, as other components are usually expressed ubiquitously. In most cases, hTERT expression is closely correlated with telomerase activity and with cancer initiation and progression.

https://www.ncbi.nlm.nih.gov / books / NBK576429

https://www.ncbi.nlm.nih.gov / books / NBK576429
Biochemistry, Telomere And Telomerase – StatPearls – NCBI Bookshelf
11 déc. 2022Telomeres are protein structures located at the ends of each eukaryotic DNA chromosomal arm. These chromosomal caps are one of the most important structures that preserve the structural integrity of linear DNA during each cycle of replication. [1] Functions of telomeres include protecting the ends of the DNA from binding to one another and to …

https://en.wikipedia.org/wiki/Telomerase

https://en.wikipedia.org/wiki/Telomerase
Telomerase – Wikipedia
Telomerase, also called terminal transferase, [1] is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3′ end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring …

https://www.nature.com/articles/s41580-020-0234-z

https://www.nature.com/articles/s41580-020-0234-z
Regulation of human telomerase in homeostasis and disease
In single-cell eukaryotes, telomerase is expressed constitutively to enable long-term cell division and viability. In metazoans, and particularly in humans, the expression of telomerase became …

https://highered.mheducation.com/sites/0073525324/student_view0/chapter21/telomerase_function.html

https://highered.mheducation.com/sites/0073525324/student_view0/chapter21/telomerase_function.html
Telomerase Function – McGraw Hill Education
Telomerase is an enzyme that adds repetitive DNA sequences to the 3′ ends of DNA on eukaryotic chromosomes. Telomerase is only expressed in cells that need to divide regularly, such as embryonic stem cells and certain cells of the immune system. Telomerase is not typically expressed in most somatic cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812681

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812681
Telomerase Mechanism of Telomere Synthesis – PMC – National Center for …
Telomerase is the essential reverse transcriptase required for linear chromosome maintenance in most eukaryotes. Telomerase supplements the tandem array of simple-sequence repeats at chromosome ends to compensate for the DNA erosion inherent in genome replication. … Other TERs are transcripts of RNA polymerase II, bearing the 5 …

https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/13:_Aging/13.02:_Telomeres

https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/13:_Aging/13.02:_Telomeres
13.2: Telomeres – Biology LibreTexts
15 mai 2022Figure 13.2.1 13.2. 1: Telomeres are found at the termini of chromosomes. The end of a telomere inserts back into the main body of the telomere to form a T-loop. (CC BY-SA 3.0; Samulili ). The DNA molecule of a typical chromosome contains a linear array of genes (encoding proteins and RNAs) interspersed with much noncoding DNA.

https://link.springer.com/referenceworkentry/10.1007/978-981-16-1313-5_47-1

https://link.springer.com/referenceworkentry/10.1007/978-981-16-1313-5_47-1
Telomerase | SpringerLink
31 mars 2023Telomerase is expressed at extremely low abundance and is probably the rarest enzyme in a human cell, even in telomerase-positive immortal cell lines that display robust telomerase activity. … When the regulation is lost and the balance disrupted, usually as a consequence of mutation, the result is invariably disease: too much …

https://www.nature.com/articles/s41576-019-0099-1

https://www.nature.com/articles/s41576-019-0099-1
Telomeres and telomerase: three decades of progress – Nature
As telomerase activity was absent in most normal tissue, and almost all human tumours (85-90%) not only constitutively expressed telomerase but also had short telomeres, the inhibition of …
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