when would you consider using tranexamic acid prophylactically ?

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429347

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429347
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Accordingly, in 2011 the World Health Organization (WHO) added TXA to its list of essential medicines. 1 In addition, the reduction of perioperative blood loss and the resulting decline in the demand for transfusions have induced European societies (Task Force for Advanced Bleeding Care in Trauma and the European Society of Anesthesiology) to pu…
PMC Free Article
Tranexamic acid (TA), 4-aminomethyl-cyclohexanecarboxylic acid, a synthetic derivative of the amino-acid lysine, has been reported to reduce bleeding in many surgical procedures, such as arthroplasty, cardioaortic surgery under cardiopulmonary bypass, and in liver transplantation by its antifibrinolytic effect. 26-32 TA prevents the plasmin …
Ultra
The aim of this RCT is to investigate whether treatment with ultra-early and short-term administration of the antifibrinolytic agent tranexamic acid (TXA), as add-on to standard, state-of-the-art SAH management, leads to a significantly higher percentage of patients with a favorable functional outcome, defined as a score of 0 to 3 on the …
Intraoperative Use of Tranexamic Acid to Reduce Transfusion Rate in Patients Undergoing Radical Retropubic Prostatectomy
Objectives To determine the efficacy of intraoperative treatment with low dose tranexamic acid in reducing the rate of perioperative transfusions in patients undergoing radical retropubic prostatectomy.. Design Double blind, parallel group, randomised, placebo controlled trial.. Setting One university hospital in Milan, Italy.. Participants 200 patients older than 18 years and undergoing …
High-dose Tranexamic Acid Reduces Blood Loss in Postpartum Haemorrhage
a PPH, postpartum haemorrhage; TA, tranexamic acid; ITT, intention to treat; PRBC, packed red blood cell. α risk: P < 0.05 using the χ 2 test or Fisher's exact test for categorical variables. Student's t -test was used in cases of normal distribution, and otherwise the Mann-Whitney U test was used for numerical variables.
Crash-2 Intracranial Bleeding Study
Introduction. The antifibrinolytic tranexamic acid has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. 1 2 These findings raise the possibility that it might be effective in other situations in which bleeding can be life threatening or disabling.
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The level of hyperoxia that can become harmful in trauma patients has not been defined, but most studies consider a PaO 2 above 200-300 mmHg (27-40 kPa) to be too high [67, 68]. … We recommend that tranexamic acid be administered to the bleeding trauma patient within 3 h after injury. (Grade 1B)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173437

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173437
The prophylactic role of tranexamic acid to reduce blood loss during …
PMC4173437 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Anesth Essays Res. 2012 Jan-Jun; 6 (1): 70-73. doi: 10.4103/0259-1162.103378

https://www.ncbi.nlm.nih.gov / pmc / articles / PMC9640392

https://www.ncbi.nlm.nih.gov / pmc / articles / PMC9640392
Effectiveness of prophylactic doses of tranexamic acid in reducing …
Results Three hundred fourteen patients underwent LSG in a high-volume center from 2016 to 2017. After introducing TXA, a statistically significant reduction in the incidence of hemorrhage during surgery was observed (22.3% vs 10.8%, p = 0.006).

https://www.rpthjournal.org/article/S2475-0379(22)01409-1/fulltext

https://www.rpthjournal.org/article/S2475-0379(22)01409-1/fulltext
Tranexamic acid evidence and controversies: An illustrated review
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding, trauma, postpartum hemorrhage, traumatic brain injury, and surgical site bleeding. Despite decades of use and a robust body of evidence, hesitancy TXA persists in many clinical settings. This illustrated review …

https://www.resmedjournal.com/article/S0954-6111(20)30302-4/fulltext

https://www.resmedjournal.com/article/S0954-6111(20)30302-4/fulltext
Prophylactic use of tranexamic acid for … – Respiratory Medicine
Prophylactic use of tranexamic acid for prevention of bleeding during transbronchial lung biopsies – A randomized, double-blind, placebo-controlled trial – Respiratory Medicine Research Article | Volume 173, 106162, November 2020 Download Full Issue

https://journals.sagepub.com/doi/10.1177/17455057231225311

https://journals.sagepub.com/doi/10.1177/17455057231225311
Prophylactic tranexamic acid for reducing intraoperative blood loss …
Il y a 3 joursThe use of low-dose tranexamic acid may be recommended for every woman with no contraindication undergoing both elective and emergency CS. There should be a generous use of tranexamic acid, especially in low- and middle-income countries to reduce the burden and costs of blood and the risks associated with blood transfusions.

https://www.nice.org.uk/guidance/qs138/chapter/quality-statement-2-tranexamic-acid-for-adults

https://www.nice.org.uk/guidance/qs138/chapter/quality-statement-2-tranexamic-acid-for-adults
Quality statement 2: Tranexamic acid for adults – NICE
History Overview Quality statements Quality statement 1: Iron supplementation Update information Download (PDF) Quality standard Next Quality statement 2: Tranexamic acid for adults Quality statement Rationale Quality measures What the quality statement means for different audiences Source guidance

https://www.nejm.org/doi/full/10.1056/NEJMoa2028788

https://www.nejm.org/doi/full/10.1056/NEJMoa2028788
Tranexamic Acid for the Prevention of Blood Loss after Cesarean …
Discussion. Among women who underwent cesarean delivery and received a prophylactic uterotonic agent, the use of tranexamic acid resulted in a significantly lower incidence of the primary outcome …

https://pubmed.ncbi.nlm.nih.gov/38279808

https://pubmed.ncbi.nlm.nih.gov/38279808
Prophylactic tranexamic acid for reducing intraoperative blood loss …
The tranexamic acid group when compared to the placebo group showed significantly lower mean blood loss (442.94 ± 200.97 versus 801.28 ± 258.68 mL; p = 0.001), higher mean postoperative hemoglobin (10.39 + 0.96 versus 9.67 ± 0.86 g/dL; p = 0.001), lower incidence of postpartum hemorrhage (1.0% versus 19.0%; p = 0.001), and lower need for use …

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06447-x

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06447-x
Can the prophylactic administration of tranexamic acid reduce the blood …
18 juin 2022The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in cardiac surgery and orthopedics confirmed this finding. The aim of this prospective, double-blind, randomized study is to evaluate the effect of on peri-and postoperative blood loss and on the incidence and severity of complications. lesoutrali bot