how tricyclic antidepressants work

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https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046983

Tricyclic antidepressants and tetracyclic antidepressants …
https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046983
Cyclic antidepressants ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression.

https://www.healthyplace.com/depression/antidepressants/tricyclic-antidepressants-how-tricyclics-work-side-effects

Tricyclic Antidepressants: How Tricyclics Work, Side …
https://www.healthyplace.com/depression/antidepressants/tricyclic-antidepressants-how-tricyclics-work-side-effects
How Tricyclic Antidepressants Work Tricyclic drugs work by increasing the brain’s supply of norepinephrine and serotonin levels – chemicals that are often abnormally low in depressed patients. Unlike some other antidepressants, tricyclics do not act by stimulating the central nervous system or by blocking monoamine oxidase.

https://www.forhims.com/blog/tricyclic-antidepressants-guide

Tricyclic Antidepressants (TCAs): A Complete Guide | hims
https://www.forhims.com/blog/tricyclic-antidepressants-guide
How Tricyclic Antidepressants (TCAs) Work Tricyclic antidepressants work by increasing the concentration of serotonin, a neurotransmitter, in your brain. Serotonin, which is sometimes referred to as the happiness chemical, is one of a large variety of neurotransmitters that are used to transmit signals between neurons , or nerve cells.

https://www.healthline.com/health/depression/tricyclic-antidepressants-tcas

Tricyclic Antidepressants (TCAs): Uses, Side Effects, and More
https://www.healthline.com/health/depression/tricyclic-antidepressants-tcas
Tricyclic antidepressants help keep more serotonin and norepinephrine available to your brain. These chemicals are made naturally by your body and are thought to affect your mood. By keeping more…

https://www.drugs.com/drug-class/tricyclic-antidepressants.html

Tricyclic Antidepressants: List, Uses & Side Effects …
https://www.drugs.com/drug-class/tricyclic-antidepressants.html
Tricyclic antidepressants (often abbreviated to TCAs) are a group of medicines that all have a similar structure and all work in a similar way. They may be used for the treatment of other conditions, not only depression.

https://en.wikipedia.org/wiki/Tricyclic_antidepressant

Tricyclic antidepressant – Wikipedia
https://en.wikipedia.org/wiki/Tricyclic_antidepressant
In summary, tricyclic antidepressants can act through NMDA antagonism, opioidergic effects, sodium, potassium and calcium channel blocking, through interfering with the reuptake of serotonin and acting as antagonists to SHAM (serotonin, histamine, alpha, muscarinic) receptors.

https://www.netdoctor.co.uk/medicines/antidepressants/a628/tricyclic-antidepressants/

Tricyclic antidepressants – Netdoctor
https://www.netdoctor.co.uk/medicines/antidepressants/a628/tricyclic-antidepressants/
The tricyclics work by preventing this reabsorption of noradrenaline and serotonin back into the nerve cells. This prolongs the mood-lightening effect of any released noradrenaline and serotonin…

https://www.sciencedirect.com/topics/neuroscience/tricyclic-antidepressants

Tricyclic Antidepressants – an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/tricyclic-antidepressants
Tricyclic Antidepressants Tricyclic antidepressants (TCAs) act by blocking primarily norepinephrine or serotonin reuptake and also affect the cholinergic and histaminergic systems (Table 55‐3). They have a narrow therapeutic index and can be associated with significant central nervous system (CNS) toxicity.

https://www.pharmacytimes.com/view/tricyclic-antidepressants-in-neuropathic-pain-the-good-the-bad-and-the-potentially-ugly

Tricyclic Antidepressants in Neuropathic Pain: The Good …
https://www.pharmacytimes.com/view/tricyclic-antidepressants-in-neuropathic-pain-the-good-the-bad-and-the-potentially-ugly
Tricyclic antidepressants elicit their antidepressant and analgesic effects by inhibiting the reuptake of serotonin and norepinephrine. Since no 2 tricyclic antidepressants are identical, knowing each medication’s receptor potencies will help determine its benefit as an antidepressant and/or neuropathic pain treatment.

https://www.verywellhealth.com/antidepressants-for-ibs-1945151

Why Antidepressants Are Used for IBS
https://www.verywellhealth.com/antidepressants-for-ibs-1945151
Tricyclic Antidepressants TCAs are the elder statesmen of antidepressants. They have well-documented anti-pain and gut-slowing qualities, which seems due to their actions on the neurotransmitters serotonin and norepinephrine. This slowing down of gut motility makes the TCAs better suited for the treatment of diarrhea-predominant IBS (IBS-D). 3